If a transsexual has been on hrt more than two or so years, he will tend to have more feminine-looking facial features, due to the way fat deposits build on his face from the estrogen. So, again, these are signs to pay attention to if you notice them. But not every transsexual will have very obviously strong brows, cheeks, or jaws. long-term follow-up of transsexual persons undergoing sex reassignment surgery cecilia dhejne et al. This one is significant due to being relatively recent, covering a 30 year span, and utilizing solid controls in the research methodology. Transsexual definition the definition of a transsexual is someone who believes they were born in the wrong gender and who wishes to change genders or has actually undergone surgery in order to change genders. transsexual (comparative more transsexual, superlative most transsexual) ( of a person ) having changed, or being in the process of changing, physical sex (because it does not match desired sex) by undergoing medical treatment such as hormone replacement therapy (hrt) and optionally sex reassignment surgery (srs), or rarely only srs. the diagnoses, for being a transsexual is not usually given by a medical doctor, but rather a doctor in psychology. Today, in the united states, many transsexuals are under loose guide lines to treat their condition. Harry benjamin, a phd who saw and diagnosed many of the behavioral symptoms, while coining the term transsexual. author, art professor, feminist, and cultural commentator camille paglia speaks on the current transgender mania, the wisdom of early medical & surgical inte.