The effect of circulating estradiol concentrations on gonadotropin secretion in young and old castrated male-to-female transsexuals. Author information (1)department of endocrinology, vrije universiteit medical center, amsterdam, the netherlands. Transgender hormone therapy of the male-to-female (mtf) type, also known as transfeminine hormone therapy, is hormone therapy and sex reassignment therapy to change the secondary sexual characteristics of transgender people from masculine or androgynous to feminine. It is one of two types of transgender hormone therapy (the other being female-to-male) and is predominantly used to treat. estrogen is an important part of many transgender womens transition process. Background transsexual persons afford a very suitable model to study the effect of sex steroids on uric acid metabolism. Design this was a prospective study to evaluate the uric acid levels and fractional excretion of uric acid (feua) in a cohort of 69 healthy transsexual persons, 22 male-to-female transsexuals (mfts) and 47 female-to-male transsexuals (fmts). effects on the body the effects of testosterone are completed over several years and a lot of factors can influence the degree of change one experiences, including the number of hormone receptors in your body, your age, the dose. Testosterone affects the entire body and it is impossible to pick some changes and not others. Conclusions the effects of cross-sex hormone treatment - in the dosages used in this study - in healthy, nonobese, young transsexual subjects do not show unequivocally that female sex steroids, given in large amounts to male subjects, have beneficial effects on cardiovascular profile and that high dose testosterone administration to female subjects is detrimental with respect to. Overview of feminizing hormone therapy ucsf transgender care ucsf health system university of california - san francisco july, 2020 hi, im dr. Maddie deutsch, associate professor of clinical family & community medicine at the university of california san francisco (ucsf), and medical director for ucsf transgender care. hrt mtf effects the impact of male to female hormones (hrt mtf) varies from person to person. However, there are some typical responses that are reasonable to expect from feminizing hormones for male-to-female persons (mtf hrt) which will be discussed here.